But after this, all those settings would be saved to the USB flash drive itself and thus won't need to be configured every time you boot from the flash drive. This includes regular tasks such as setting up user accounts and passwords and configuring network settings. When you boot up Windows 10 from USB for the flash drive for the first time, you'll need to do a little bit of an initial setup. It's important to note some pointers here. When the process is finally finished, you can use this flash drive to boot (and run) a fully-working copy of Windows 10 on any computer. Step 3: The process of creating the bootable Windows 10 USB may take a few minutes. Finally, click Next to start copying essential Windows 10 files to the flash drive. One prominent feature is that it allows you to create a Windows To Go drive on certified and non-certified USB sticks. Once this is done, you have to select the flash drive as both system and boot partition. Simply put, WinToUSB is a popular freemium tool developed by Hasleo software and it it an one-stop solution for creating portable Windows to Go drive so that you can run Windows OS directly from USB or hard disk. Step 2: After plugging in the flash drive into the USB port of the computer, select it in WinToUSB and format it. On running the utility, you have to specify the location of the Windows 10 ISO or the installation disc. Step 1: Download and install WinToUSB from its website. Here's how to create a portable Windows 10 installation using WinToUSB. Microsoft announces Windows 10 Creators Update with advanced 3D features To get this done, all you need is a USB flash drive (preferably 16B or higher in capacity) and a Windows 10 installation disc (or ISO file).